Reviewing previous research efforts, this session sets out a blueprint for the role of research, policy, and law in advancing the civic, economic and social participation of persons with disabilities in a global society. It reviews past public policy efforts and research findings regarding workers with disabilities. It discusses current and future research initiatives on the cutting edge of promoting successful employment outcomes for people with disabilities. The discussion presents promising research methodologies in multidisciplinary field disability and employment research. Finally, our presenter will put forth challenges and opportunities for research, policy, and legal initiatives, framing a blueprint for the next quarter century.